Pituitary Gland.
Endocrine System
The hypothalamus of the brain releases TRH (thyroid releasing hormone) which causes the pituitary to release TSH (thyroid stimulating hormone) which causes the thyroid to use iodine, magnesium, zinc, and TPO (thyroid peroxidase) to make 7% T3 and 93% T4.
Thyroid binding globulin (TGB) transports T4 to the liver, stomach and peripheral tissues where the liver converts 65% of T4 to T3,
20% of T4 is converted to T3S and T3AC (inactive 14 form) which is then converted to T3 in the gastrointestinal tract.
The other 15% of T4 goes to reverse T3 (inactive).
The adrenal glands work interactively with the hypothalamus and the pituitary gland.
For the adrenal glands to produce corticosteroid hormones, the hypothalamus produces corticotrophin.
Corticotropin causes the release of hormones from the pituitary gland.
In turn, the pituitary gland produces corticotrophin hormones that stimulate the adrenal glands.
Then the adrenal glands make and release corticosteroid hormones.
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